Arizona’s attorney general on Wednesday asked the U.S. Supreme Court to force the Sackler family, which owns OxyContin-maker Purdue Pharma, to return billions of dollars they took out of the company.

The court filing marks the first time the high court has been asked to weigh in directly on the nation’s opioid crisis.

Arizona Attorney General Mark Brnovich said the filing is meant to ensure that Purdue has enough money to pay any future judgments or settlements. Nearly all other opioid-related cases brought by states, including a separate one filed last year by Arizona, are in state courts.

“We need to do everything we can to stop the opioid manufacturers from profiting from this crisis,” Brnovich said in an interview. “They have siphoned off billions of dollars from the company, and I want to make sure that any money will end up with states and victims of the crisis — not in an account in the Cayman Islands or a Swiss bank.”

A spokesman for the Sackler family said they deny the allegations in the claim. Brandon Messina said Arizona’s claims are “inconsistent with the factual record.”

The filing is the latest maneuver from a state seeking to hold the drug industry accountable for a crisis that costs more American lives each year than vehicle crashes.

“It’s a power play,” Abbe Gluck, a law professor at Yale Law School, said of Arizona’s filing with the Supreme Court.

She said a ruling by the high court on the opioid issue, although a longshot, would have national impact.

Attorney Travis Lenkner, managing partner at a Chicago law firm representing Arizona in the Supreme Court case, said there were concerns that Sackler family members were sending some of the money abroad.